论文部分内容阅读
目的:探讨血清肿瘤坏死因子a(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)水平与复发性阿弗他溃疡(RAU)患者免疫功能的关系。方法:收集我院于2015年6月~2016年6月间收治的82例RAU患者作为观察组,另取80例健康体检人员作为对照组,比较两组血清TNF-α、IL-6,8、CD3~+、CD4~+、CD8~+、CD4~+/CD8~+水平,并分析各指标的相关性。结果:观察组血清TNF-α、IL-6、IL-8、CD8~+水平均高于对照组,差异均有统计学意义(P<0.05)。观察组CD4~+、CD4~+/CD8~+水平低于对照组,差异均有统计学意义(P<0.05);两组CD3~+水平比较,差异无统计学意义(P>0.05)。血清TNF-α、IL-6,8水平与CD3~+、CD4~+、CD8~+、CD4~+/CD8~+均呈负相关(P<0.05)。结论:RAU疾病的发生与机体免疫功能障碍有关,检测患者TNF-α、IL-6,8水平可反映出患者免疫功能水平。
Objective: To investigate the relationship between serum TNF-α, IL-6, IL-8 levels and immune function in patients with recurrent aphthous ulcer (RAU). Methods: Totally 82 RAU patients admitted from June 2015 to June 2016 in our hospital were selected as the observation group and another 80 healthy people as the control group. The levels of serum TNF-α, IL-6, , CD3 ~ +, CD4 ~ +, CD8 ~ +, CD4 ~ + / CD8 ~ +, and analyzed the correlation of each index. Results: The levels of serum TNF-α, IL-6, IL-8 and CD8 + in the observation group were significantly higher than those in the control group (P <0.05). The levels of CD4 ~ + and CD4 ~ + / CD8 ~ + in the observation group were lower than those in the control group (P <0.05). There was no significant difference in the levels of CD3 + between the two groups (P> 0.05). The levels of serum TNF-α and IL-6,8 were negatively correlated with the levels of CD3 +, CD4 +, CD8 +, CD4 + / CD8 + (P <0.05). Conclusion: The occurrence of RAU is related to immune dysfunction. Detecting the level of TNF-α and IL-6,8 in patients can reflect the level of immune function.