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目的观察垂体后叶素联合卡前列素氨丁三醇治疗胎盘早剥产后大出血的临床疗效。方法选取医院胎盘早剥产后大出血患者92例,随机分为观察组和对照组,每组46例。对照组采用卡前列素氨丁三醇治疗,观察组采用卡前列素氨丁三醇+垂体后叶素治疗。观察2组产后出血量、第三产程及止血时间,比较2组不良事件发生率。结果与对照组比较,观察组产后15 min、2 h、24 h出血量均显著减少,第三产程及止血时间均明显缩短,差异有统计学意义(P<0.01);观察组不良事件发生率明显低于对照组,差异有统计学意义(P<0.01)。结论联合应用垂体后叶素与卡前列素氨丁三醇治疗胎盘早剥产后大出血患者疗效显著,可显著降低产后出血量及不良事件发生率,保障母婴安全。
Objective To observe the clinical efficacy of pituitrin combined with carboprost trometamol in the treatment of postpartum hemorrhage after placental abruption. Methods Ninety-two patients with major bleeding after hospitalized placental abruption were randomly divided into observation group and control group, with 46 cases in each group. The control group was treated with carboprost tromethamine, and the observation group was treated with carboprost trometamol and pituitrin. Postpartum hemorrhage, the third stage of labor and bleeding time were observed in two groups. The incidence of adverse events in two groups were compared. Results Compared with the control group, the amount of bleeding in the observation group decreased significantly at 15 min, 2 h and 24 h postpartum, and the duration of the third stage of labor and bleeding stopped significantly (P <0.01). The incidence of adverse events in the observation group Significantly lower than the control group, the difference was statistically significant (P <0.01). Conclusion The combination of pituitrin and carboprost trometamol in the treatment of postpartum hemorrhage placental abortion significantly curative effect, can significantly reduce the incidence of postpartum hemorrhage and adverse events, to protect the safety of mother and child.