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先天性白内障是一类严重影响患者视力的先天性疾病,近年研究表明连接蛋白与其发生有关。连接蛋白是一类由多基因家族编码的蛋白质,分子结构具有同源性。本文对晶体中分布的3种连接蛋白和先天性白内障发生的关系及可能的机制进行综述。
Congenital cataracts are a group of congenital diseases that seriously affect the visual acuity of patients. Recent studies show that connexins are involved in their development. Connexins are a class of proteins encoded by multiple gene families that share homology in molecular structure. This article reviews the relationship between the three connective proteins distributed in the crystal and the occurrence of cataract and possible mechanisms.