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乙胺碘呋酮治疗后发生的各种心外科副作用已有报道。长期使用乙胺碘呋酮治疗的患者中有15~40%出现无症状的肝功能异常。其血清转氨酶增高是可逆的且与剂量有关,所以一般无需停药。据报道乙胺碘呋酮可引起细胞毒性和胆汁郁积性肝损害,提示脂肪变性和类似酒精性肝炎或胆汁郁积性肝炎的改变可能是日服该药引起的近期副作用,而小结性肝硬变则系其远期副作用。作者报道2例患者在静脉给予乙胺碘
A variety of cardiac surgery side effects have been reported after amiodarone treatment. Long-term use of amiodarone-treated patients 15 to 40% of asymptomatic liver dysfunction. The increase in serum aminotransferases is reversible and dose-related, so generally without stopping. It has been reported that amiodarone causes cytotoxicity and cholestatic liver damage suggesting that changes in steatosis and alcohol-like hepatitis or cholestatic hepatitis may be the immediate side effects of the drug on a daily basis and that the nodular cirrhosis It is its long-term side effects. The authors report that 2 patients were given intravenous ethylamine