分别以骨痛灵高、低剂量给予涂药 ,以正骨水及 80 %乙醇涂抹作对照 ,观察骨痛灵的消肿、止痛作用。结果 :对蛋清致大鼠足肿胀和二甲苯致小鼠耳肿胀 ,以及对大鼠光热辐射致痛和小鼠热板致痛 ,高剂量骨痛灵与正骨水均有显著的消肿及止痛作用 ,且骨痛灵组优于正骨水组 ,但骨痛灵低剂量作用持续时间明显缩短。为临床局部涂擦骨痛灵消肿、止痛提供实验依据。 High-dose and low-dose Lingtongling were used to apply the drug, and bone water and 80% ethanol were applied as controls to observe the effect of Gutongling on swelling and analgesia. RESULTS: Foot swelling and xylene-induced mouse ear swelling were induced in egg whites, and photothermal radiation induced pain in rats and pain in mice with hot plate. High doses of Gutongling and Zhenggushui both had significant swelling. The analgesic effect was better in the Gutongling group than in the Zhenggushui group, but the duration of the low-dose effect of Gutongling was significantly shortened. It provides experimental basis for the local application of rubbing bone pain relief and pain relief.