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美《化学与工程》第57卷第10期第17页(1979年)报道:白喉致病微生物白喉棒状杆菌利用其多肽类毒素从宿主细胞摄取营养,并释放毒素至易感部位。毒素的一个亚单位在某些哺乳类动物细胞中抑制蛋白合成。毒素作用的首先问题是如何穿过细胞膜,释放抑制作用的亚单位。得克萨斯大学卫生中心的艾德斯(Leon Eidels)等人根据动物实验,认为白喉毒素的干扰作用是先找到一个膜受体,即豚鼠细胞膜上的特殊糖蛋白,然后跨在膜受体上。在体外实验中,毒素与特殊糖蛋
US Chemical and Engineering Vol. 57, No. 10, p. 17 (1979) reports that C. diphtheriae, a causative microorganism of diphtheria, uses its polypeptide toxoid to take nutrients from host cells and release toxins to susceptible sites. A subunit of toxin inhibits protein synthesis in some mammalian cells. The first problem with toxin action is how to cross the cell membrane to release the inhibitory subunits. Based on animal experiments, Leon Eidels et al. From the University of Texas Health Center found that the interference of diphtheria toxin is to find a membrane receptor, a special glycoprotein on the membrane of guinea pig cells, and then straddles membrane receptors. In vitro experiments, toxins and special glycoproteins