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本文报道了基于新靶点或应用前药策略所发现的几种具有发展前景的抗肿瘤化学实体。细胞信号转导中 ,酪氨酸激酶、蛋白磷酸化酶Cdc2 5 ,以及抗肿瘤血管形成等都是研究新型抗肿瘤药物的热点 ,针对这些重要靶点发现了新的化学实体。同时 ,针对细胞复制过程中微管和有丝分裂中纺锤体形成的抗肿瘤药物研究也有了新的进展。针对多柔比星和喜树碱等临床应用抗肿瘤药物发展起来的前药具有毒性小、药效高、药代动力学稳定性好等特点
In this paper, we report several promising antitumor chemical entities based on new targets or using prodrug strategies. Cell signal transduction, tyrosine kinase, protein phosphorylase Cdc2 5, and anti-tumor angiogenesis are new hot topics in the research of new antitumor drugs. New chemical entities have been discovered for these important targets. At the same time, new progress has been made in the research of antitumor drugs formed by spindle in mitosis and mitosis during cell replication. Prodrugs developed for the clinical use of anticancer drugs such as doxorubicin and camptothecin have the advantages of low toxicity, high efficacy and good pharmacokinetic stability