腹水癌细胞采用小分子化合物或直接利用嘌呤环的两种不同过程进行核苷酸的生物合成,此种代谢特点暗示着化疗药物的抗肿瘤作用必须能同时阻断肿瘤细胞合成核苷酸时的两个过程。作者选用6-氯嘌呤和重氮丝氨酸合併试用于5种小白鼠的腹水癌。重氮丝氨酸固定为0.4mg/kg,氯嘌呤以10—200mg/kg不同的剂量配合应用,存活期作为肿瘤受抑制指标,同时尚采用总细胞容积量和细胞形态学的观察。 Ascitic cancer cells use two different processes of small molecule compounds or direct use of purine ring for nucleotide biosynthesis. This metabolic feature suggests that the anti-tumor effect of chemotherapeutic drugs must simultaneously block the synthesis of nucleotides by tumor cells Two processes. The author selected 6-chloropurine and diazo-serine combined test for 5 kinds of mouse ascites cancer. Diazepam fixed at 0.4mg / kg, chloropurine with different dosages of 10-200mg / kg with the survival as a tumor inhibition index, while still using the total cell volume and cell morphology observed.