双(氯乙基)胺的衍生物(氮芥类)对腫瘤的实验及临床治疗,都有显著功效,惟毒性高,治疗范围不广是其缺点。为了增强这类化合物的细胞毒素烷化作用並减低其毒性,等曾研究了一系列氯乙胺的杂环衍生物,他们发现5-双(β-氯乙基)胺基6-甲基2,4-二氧嘧啶即多潘,具有极显著的腫瘤生长抑制作用,但此化合物的合成方法,迄今尚未发表。 Derivatives of bis (chloroethyl) amine (nitrogen mustard) on tumor experiments and clinical treatment, have significant efficacy, but high toxicity, the treatment is not wide is its shortcomings. In order to enhance the cytotoxic alkylation of these compounds and reduce their toxicity, a series of heterocyclic derivatives of chloroethylamine have been studied. They found that 5-bis (β-chloroethyl) amino 6-methyl 2 , 4-dioxopyrimidine that is more pan, has a very significant tumor growth inhibitory effect, but the synthesis of this compound has not yet been published.