论文部分内容阅读
[目的]比较甲地孕酮联合昂丹司琼与单用昂丹司琼治疗化疗中呕吐的疗效和病人生活质量。[方法]80例肿瘤病人被随机分成联合甲地孕酮组(40例)和单用昂丹司琼组(40例),联合甲地孕酮组:自化疗当日早晨每日口服甲地孕酮160mg,连续10d,昂丹司琼8mg化疗前半小时静脉推注,21d为1个周期。单用昂丹司琼组仅用昂丹司琼。[结果]联合甲地孕酮组和单用昂丹司琼组急性呕吐发生率分别是35.0%和60.0%,差异有显著性(P<0.05),其中Ⅲ度以上发生率分别是2.5%和7.5%,无显著性差异(P>0.05)。迟发性呕吐发生率分别是27.5%和57.5%(P<0.01),其中Ⅲ度以上呕吐发生率分别是0和10.0%,均有显著性差异。联合甲地孕酮组食欲、KPS和体重明显改善。[结论]在肿瘤化疗中,甲地孕酮联合昂丹司琼比单用昂丹司琼止吐疗效较好,尤其对迟发性呕吐效果更加明显,同时明显提高病人生活质量。
[Objective] To compare the efficacy of megestrol combined with ondansetron and ondansetron in the treatment of vomiting in chemotherapy and quality of life of patients. [Method] Eighty patients with cancer were randomly divided into combined megestrol (40 cases) and ondansetron alone (40 cases), combined with megestrol group: daily since the day of chemotherapy, Ketone 160mg, continuous 10d, ondansetron 8mg half an hour before chemotherapy, intravenous injection, 21d for a cycle. Ondansetron alone ondansetron alone. [Results] The incidence rates of acute emesis in the combined megestrol-treated group and ondansetron-only group were 35.0% and 60.0%, respectively (P <0.05), with the incidence of Ⅲ degree or above being 2.5% and 7.5%, no significant difference (P> 0.05). The incidences of delayed emesis were 27.5% and 57.5%, respectively (P <0.01). The incidence of grade Ⅲ or higher emesis was 0 and 10.0%, respectively, with significant differences. In combination with megestrol, appetite, KPS and body weight were significantly improved. [Conclusion] The combination of megestrol plus ondansetron is better than ant to vomiting alone with ondansetron, especially for delayed emesis, and significantly improve the quality of life of patients.