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目的：为观察异体胎儿真皮临床应用的可行性．方法：通过１９例经胰蛋白酶处理的冷冻异体胎儿真皮与自体表皮重组复合皮，并以单纯自体表皮为对照，作移植实验和动态观察．结果：复合皮移植后抗感染力强，成活率与自体表皮移植组无显著性差异（Ｐ＞０．０５），且可防止组织收缩和疤痕形成．同时提出异体胎儿真皮移植首先应满足血型的一致，否则对复合皮质量产生影响．结论：经胰蛋白酶处理的冷冻异体胎儿真皮可作自体表皮移植的载体，是理想的真皮替代物．临床应用异体胎儿真皮一次性完成复合皮移植术，提高了植皮外形效果，节省了患者的皮源，可以临床推广应用．
Objective: To observe the feasibility of clinical application of allogeneic fetal dermis. Methods: Twenty-nine cases of frozen allogeneic fetal dermis and autologous epidermis were treated with trypsin. The autologous epidermis was used as a control for transplantation experiments and dynamic observation. Results: The anti-infective ability of composite skin graft was higher than that of autologous epidermal transplantation group (P> 0.05), and the tissue shrinkage and scar formation could be prevented. At the same time, allogeneic fetus dermal grafts should first meet the same blood group, otherwise the quality of the composite skin impact. CONCLUSION: The frozen allogeneic fetus dermis treated with trypsin can be used as a carrier for autologous epidermal transplantation and is an ideal dermal substitute. Clinical application of allogeneic fetal dermis to complete a one-time composite skin graft surgery to improve the appearance of skin graft shape, saving the patient’s skin source, can be clinically applied.