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目的探讨采用内镜下5-氟尿嘧啶(FU)缓释化疗粒子注射对晚期消化道肿瘤患者进行治疗的临床效果。方法随机选取郑州大学附属郑州中心医院2012年9月至2014年7月期间郑州大学附属郑州中心医院收治的晚期消化道肿瘤患者80例,采用内镜下5-FU缓释化疗粒子植入方法对所有患者进行治疗,并对患者的临床症状改善情况进行观察记录。结果本研究中食管癌患者总治疗有效率为88.89%,贲门胃底癌为81.82%,胃癌为76.47%,直肠癌为66.67%;患者经治疗,其疼痛程度明显减轻,体重较治疗前改善明显(P<0.05)。结论采用内镜下5-FU缓释化疗粒子注射治疗晚期消化道肿瘤,疗效显著,安全可靠,建议在临床上进一步推广。
Objective To investigate the clinical effect of endoscopic fluorouracil (FU) sustained-release chemotherapy particle injection on patients with advanced gastrointestinal cancer. Methods Eighty patients with advanced gastrointestinal cancer admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from September 2012 to July 2014 were selected randomly from Zhengzhou Central Hospital of Zhengzhou University from September 2012 to July 2014. The method of particle implantation with 5-FU 5-FU All patients were treated, and the patient’s clinical symptoms were observed and recorded. Results In this study, the total effective rate of esophageal cancer patients was 88.89%, gastric cardia gastric fundus was 81.82%, gastric cancer was 76.47%, and rectal cancer was 66.67%. After treatment, the pain was relieved and the body weight was significantly improved (P <0.05). Conclusion The endoscopic 5-FU sustained-release chemotherapy particles in the treatment of advanced gastrointestinal cancer, significant effect, safe and reliable, it is recommended to further promote the clinical.