1902年Richet在提出“过敏症”这一概念时,指出了神经系统在其发生中的意义,他写道:“就其本质来讲,过敏症的一切症状,属于神经系统的急性中毒。”稍后,俄国的免疫学家(1907),提出“过敏性休克”这一术语时证明,往致敏动物的大脑组织内或硬脑膜下注射决定量抗元,可以引起过敏性休克,而在乙醚麻醉状态下,接受决定量抗元 In his introduction of the concept of “allergy” in 1902 Richet pointed out the significance of the nervous system in its development, he wrote: “By its very nature, all the symptoms of allergies are acute nervous system poisoning.” Later, the Russian immunologist (1907), who proposed the term “anaphylactic shock”, demonstrated that the injection of a defined amount of anti-methotrexate into the brain tissue of the sensitized animal or subdural can cause anaphylactic shock, whereas in the Under ether anesthesia, accept the decisive amount of anti-Yuan