血管生成因子 ,诸如成纤维细胞生长因子 (FGF)和血管内皮生长因子 (VEGF)是目前研究的一大热点。人们试图通过抑制它们来抑制疾病中病态的血管形成 ,例如癌症中的血管形成。FGF和VEGF是通过特异性地结合于那些表达在细胞表面上的受体而发挥作用 ,这些受体都具有酪氨酸激酶活性。这些受体激酶活性的活化使得它们与下游的信号转导途径偶联 ,而这些途径调节着内皮细胞的增殖、迁移和分化。对FGF和VEGF介导的信号转导途径的抑制剂目前正在进行临床试验。本文主要对现在已知的FGF和VEGF介导的信号转导途径作一综述 ,这些途径均导致特定的生物学效应。此外 ,还将讨论目前已知的这些途径调节血管生成的方式 Angiogenic factors such as fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) are the hot topics in the current research. People try to suppress the morbid angiogenesis in the disease by inhibiting them, such as the angiogenesis in cancer. FGF and VEGF function by specifically binding to those receptors expressed on the cell surface, all of which have tyrosine kinase activity. Activation of these receptor kinases allows them to be coupled to downstream signaling pathways, which regulate the proliferation, migration and differentiation of endothelial cells. Inhibitors of FGF and VEGF-mediated signal transduction pathways are currently undergoing clinical trials. This review focuses on the currently known FGF and VEGF-mediated signal transduction pathways, all of which lead to specific biological effects. In addition, the ways in which these pathways are currently known to regulate angiogenesis will also be discussed