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探讨应激状态下血清白细胞介素２（ＩＬ２）含量变化及其与多器官衰竭（ＭＯＦ）的关系。应用酶联免疫吸附法（ＥＬＩＳＡ）测定４５例急性危重病患者应激状态下血清ＩＬ２含量的动态变化。结果：急性危重患者血清ＩＬ２水平于第１天即明显下降（Ｐ＜０．０１），第３～５天达最低浓度；ＩＬ２含量下降与应激严重程度呈负相关；ＭＯＦ患者于应激早期血清ＩＬ２下降程度较非ＭＯＦ者更为显著。提示：动态观察血清ＩＬ２含量变化有助于了解患者病情程度和预后判断。
To investigate the changes of serum interleukin 2 (IL2) and its relationship with multiple organ failure (MOF) under stress. Serum levels of IL2 in 45 acute critically ill patients were measured by enzyme-linked immunosorbent assay (ELISA). Results: Serum levels of IL2 in acute critically ill patients decreased significantly (P <0.01) on day 1 and reached the lowest level on days 3 to 5; the decrease of IL2 level was negatively correlated with the severity of stress; Serum IL2 decreased more significantly than non-MOF. Tip: Dynamic observation of serum IL2 levels help to understand the patient’s condition and prognosis.