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目的探讨MMP-9、TIMP-1和VEGF蛋白的表达与子宫内膜腺癌临床病理特征的关系及意义。方法实验分为正常子宫内膜组20例和子宫内膜腺癌组84例,通过免疫组织化学染色方法检测两组子宫内膜中MMP-9、TIMP-1和VEGF蛋白的阳性表达强度,分析其表达与子宫内膜腺癌的临床分期、病理分级、肌层浸润及有无淋巴结转移的关系。结果与正常子宫内膜组比较,子宫内膜腺癌组MMP-9和VEGF的蛋白阳性表达明显增高,TIMP-1蛋白阳性表达明显降低,差异均有统计学意义(P<0.01),且3种蛋白的阳性表达均与分期、分级、浸润深度及转移程度有关。结论 MMP-9、VEGF蛋白的高表达和TIMP-1蛋白的低表达说明这3种蛋白参与了子宫内膜腺癌的发生发展,其机制有待于进一步研究。
Objective To investigate the relationship between the expression of MMP-9, TIMP-1 and VEGF and clinicopathological features of endometrial adenocarcinoma. Methods The experiment was divided into normal endometrium group (20 cases) and endometrial adenocarcinoma group (84 cases). Immunohistochemical staining was used to detect the expression of MMP-9, TIMP-1 and VEGF in the two groups of endometrium. The expression of endometrial adenocarcinoma with clinical stage, pathological grade, myometrial invasion and lymph node metastasis. Results Compared with normal endometrium group, the protein expression of MMP-9 and VEGF in endometrial adenocarcinoma group was significantly higher than that in normal endometrium group (P <0.01), and the positive expression of TIMP-1 protein was significantly decreased The positive expression of seed proteins were related to staging, grading, depth of invasion and metastasis. Conclusion The overexpression of MMP-9, VEGF and the low expression of TIMP-1 protein suggest that these three proteins are involved in the development of endometrial adenocarcinoma. The mechanism remains to be further studied.