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目的研究采用米非司酮联合甲氨喋呤保守治疗宫外孕的疗效。方法将我院2011年9月~2012年9月收治的94例宫外孕按照1:1的人数比随机分为实验组和对照组,实验组在肌注甲氨蝶呤的基础上加服米非司酮,对照组单用甲氨蝶呤,比较两组的疗效和不良反应情况。结果实验组有42例血HCG均值由治疗前的1962.7±1255.2IU/L下降为治疗后的701.3±514.8IU/L,明显下降,有的已经接近正常值;包块直径也由4.0±2.5cm缩减为0.25±0.13cm,直径明显缩小,对照组的疗效情况不甚理想。结论米非司酮联合甲氨喋呤治疗宫外孕相较于单独使用甲氨蝶呤治疗宫外孕治愈率更高,副反应轻,住院时间缩短,值得临床推广。
Objective To study the efficacy of conservative treatment of ectopic pregnancy with mifepristone combined with methotrexate. Methods 94 cases of ectopic pregnancy treated in our hospital from September 2011 to September 2012 were randomly divided into experimental group and control group according to the ratio of 1: 1. The experimental group was given mifepristone on the basis of intramuscular injection of methotrexate Division ketone, control group methotrexate alone, the two groups were compared efficacy and adverse reactions. Results In the experimental group, the mean blood HCG in 42 cases decreased from 1962.7 ± 1255.2 IU / L before treatment to 701.3 ± 514.8 IU / L after treatment, and the mean value of HCG in the experimental group was almost normal; the diameter of the mass was also 4.0 ± 2.5 cm Reduced to 0.25 ± 0.13cm, the diameter was significantly reduced, the efficacy of the control group less than ideal. Conclusion The combination of mifepristone and methotrexate in the treatment of ectopic pregnancy compared with methotrexate alone treatment of ectopic pregnancy higher cure rate, less side effects, shorter hospital stay, worthy of clinical promotion.