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为探讨哮喘患者血清细胞因子在哮喘发病中的作用及与IgE的相关关系,分别在哮喘发作期,缓解期及口服强的松治疗后用ELISA夹心法分别测定血清中IL-4、sICAM-1、IFNr和IgE水平。结果在哮喘发作期IL-4、sICAM-1、IgE水平明显升高,三者呈明显正相关;IFNr水平明显降低,与IL-4呈明显负相关:而缓解期IL-4、sICAM-1、IgE明显降低、IFNr明显升高;经强的松治疗后IL-4、sICAM-1和IgE水平明显降低,而IFNr水平有所升高。提示IL-4在哮喘发作中起重要作用,而IFNr起重要保护作用,IL-4可促进sIGAM-1和IgE的表达和分泌,而抑制IFNr的产生。所以,检测哮喘患者血清IL-4、sICAM-1、IFNr和IgE,不但可监测病情和判定疗效,而且能指导哮喘的预防和治疗。
To investigate the role of serum cytokines in the pathogenesis of asthma and its relationship with IgE in asthmatic patients, serum levels of IL-4 and sICAM-1 were measured respectively by ELISA sandwich method after asthma attack, remission and oral prednisone treatment , IFNr and IgE levels. Results The levels of IL-4, sICAM-1 and IgE in the asthma attack stage were significantly increased, and the levels of IL-4 and sICAM-1 in remission stage were significantly negatively correlated with IL-4 , IgE was significantly reduced, IFNr significantly increased; after prednisone treatment IL-4, sICAM-1 and IgE levels were significantly lower, while the level of IFNr increased. It is suggested that IL-4 plays an important role in asthmatic attacks and IFNr plays an important protective role. IL-4 can promote the expression and secretion of sIGAM-1 and IgE and inhibit the production of IFNr. Therefore, the detection of serum IL-4, sICAM-1, IFNr and IgE in patients with asthma can not only monitor the disease and determine the efficacy, but also guide the prevention and treatment of asthma.