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目的 :观察不同乙肝病毒载量的轻度慢性乙型病毒性肝炎(CHB)患者肝组织中细胞转化生长因子 β1(TGF -β1)表达的区别。方法 :检测87例轻度CHB患者血清HBVDNA并同期行肝穿刺 ,采用免疫组化技术检测肝组织中TGF -β1的蛋白表达。结果 :血清HBVDNA>1×10 3 拷贝/mL组 (61例 )与血清HBVDNA≤1×103拷贝组/mL(26例 )肝组织TGF -β1表达差别无统计学意义 (P>0.05)。结论 :乙肝病毒载量对轻度慢性乙型肝炎患者肝组织TGF -β1表达无显著影响。
Objective: To observe the difference of the expression of transforming growth factor-β1 (TGF-β1) in liver tissue of patients with mild chronic hepatitis B (CHB) with different hepatitis B viral load. Methods: Serum HBVDNA was detected in 87 patients with mild CHB and hepatic puncture was performed in the same period. The protein expression of TGF-β1 in liver tissues was detected by immunohistochemistry. Results: There was no significant difference in the expression of TGF-β1 between the HBVDNA> 1 × 10 3 copies / mL group and the serum HBVDNA≤1 × 103 copies / mL group (26 cases) (P> 0.05). Conclusion: The hepatitis B virus load has no significant effect on the expression of TGF-β1 in the liver of mild chronic hepatitis B patients.