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以氟氧头孢中间体(6R,7R)-7-[2-[(二氟甲基)硫基]乙酰胺基]-3-[[[1-(2-羟基乙基)-1H-四唑-5-基]硫基]-甲基]-7-甲氧基-8-氧代-5-氧杂-1-氮杂二环[4.2.0]辛-2-烯-2-羧酸二苯甲基酯(2)为原料,经三氟乙酸脱除二苯甲基得羧酸,加入成盐剂异辛酸钠和晶种,再加入二氯甲烷析出产品,经过滤、洗涤、干燥制得高纯度广谱抗生素氟氧头孢钠。工艺条件温和,过程稳定,工艺操作简单,易于产业化。
(6R, 7R) -7- [2 - [(difluoromethyl) thio] acetamido] -3 - [[[1- (2-hydroxyethyl) 5-yl] thio] -methyl] -7-methoxy-8-oxo-5-oxa-1-azabicyclo [4.2.0] oct-2-ene-2-carboxy Acid diphenylmethyl ester (2) as raw material, the benzhydryl group is removed by trifluoroacetic acid to obtain carboxylic acid, adding sodium salt of isooctanoate and seed crystal, and then adding methylene chloride to precipitate the product, filtering, washing, Dry preparation of broad-spectrum antibiotic fluoroquinolone sodium. Gentle process conditions, process stability, process operation is simple, easy to industrialization.