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目的:对比观察连翘提取物的解热作用,探讨连翘提取物研究中适用的发热模型及推测可能的作用机制。方法:建立酵母(2 g/kg)、脂多糖(LPS)(20μg/kg)致大鼠发热模型,分别测量大鼠的肛温,考察造模后灌胃给药10m L/kg生理盐水、0.2 g/kg阿司匹林、1.25,2.5,5 g/kg连翘提取物后不同时间内大鼠的体温变化。结果:酵母和LPS致热模型制作成功,1.25,2.5 g/kg连翘提取物对发热模型动物的体温影响较小,5 g/kg连翘提取物和阿司匹林可减缓发热模型动物的体温升高趋势,对LPS致热模型的解热作用更显著。结论:连翘提取物对酵母和LPS致热模型有解热作用,对LPS致热模型的解热作用较酵母致热模型更显著,推测其可能是通过抑制PGE2的合成和释放来发挥解热作用。
OBJECTIVE: To compare the antipyretic effects of Forsythia suspensa extract, to explore the applicable fever model in Forsythia suspense extract and to speculate the possible mechanism of action. Methods: Rat model of fever induced by yeast (2 g / kg) and lipopolysaccharide (LPS) (20 μg / kg) was established. The rectal temperature of rats was measured. After intragastric administration of 10 m L / kg normal saline, 0.2 g / kg aspirin, 1.25, 2.5, 5 g / kg Forsythia extract after different time rat body temperature changes. RESULTS: Yeast and LPS-induced pyrexia models were successfully produced. Forsythia suspensa extract at 1.25 and 2.5 g / kg had little effect on body temperature of pyrexia model animals. 5 g / kg Forsythia suspensa extract and aspirin attenuated body temperature increase Trend, the antipyretic effect of the LPS pyrogenic model is more significant. CONCLUSION: Forsythia suspensa extract has antipyretic effect on yeast and LPS-induced pyrogenic model, and the antipyretic effect on LPS-induced pyrogenic model is more significant than that on yeast induced model. It is speculated that Forsythia suspensa extract may exert antipyretic effect by inhibiting the synthesis and release of PGE2 effect.