单克隆免疫球蛋白病由一组异质性疾病组成,其特征在于B淋巴细胞或浆细胞克隆性增殖产生免疫球蛋白。大多数患者血液或尿液中可检测到单克隆免疫球蛋白。具有临床意义的单克隆免疫球蛋白病疾病谱广泛(图1)、疾病表现多样,可侵及多器官,如心脏,肝脏,皮肤,肾脏和神经等,而且大多为少见甚至是罕见疾病,早期诊断与及时干预有助于改善预后。 Monoclonal immunoglobulin diseases consist of a heterogeneous group of diseases characterized by clonal expansion of B lymphocytes or plasma cells to produce immunoglobulins. Monoclonal immunoglobulins are detectable in the blood or urine of most patients. Clinical manifestations of monoclonal immunoglobulin disease spectrum is broad (Figure 1), the disease performance is diverse, can invade and multiple organs, such as heart, liver, skin, kidney and nerve, etc., and most are rare or even rare diseases, early Diagnosis and timely intervention help to improve the prognosis.