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目的 :研究不同剂量氟伐他汀调整高脂血症的疗效及不良反应。方法 :氟伐他汀 4 0mgq .n .组 37例 ,2 0mgq .n .组33例 ,服药 4周。结果 :4 0mg组服药后血清总胆固醇降低32 .4 % ,2 0mg组降低15 .7% ,P <0 .0 5。两组降低甘油三酯及升高高密度脂蛋白胆固醇的差异不显著。结论 :氟伐他汀 4 0mgq .n .降低血清总胆固醇的作用明显优于氟伐他汀 2 0mgq .n .。
Objective: To study the efficacy and side effects of different doses of fluvastatin on hyperlipidemia. Methods: Fluvastatin 40 mg / kg in group 37 and 20 mgq in group 33 were given for 4 weeks. Results: Serum total cholesterol was reduced by 32.4% in 40 mg group and 15.7% in 20 mg group (P <0.05). There was no significant difference between the two groups in reducing triglycerides and increasing high-density lipoprotein cholesterol. Conclusion: The effect of fluvastatin 4 0mgq .n. To reduce serum total cholesterol is better than that of fluvastatin 20mgq. N.