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目的观察核黄素磷酸钠注射液联合布拉氏酵母菌散剂治疗小儿轮状病毒肠炎(RVE)的临床疗效。方法将78例RVE患儿随机分为对照组和治疗组各39例。两组均行抗病毒等常规治疗。对照组患儿口服布拉氏酵母菌散剂,<1岁0.125g/次、2次/d,1~3岁0.25g/次、2次/d。治疗组在对照组基础上联合核黄素磷酸钠注射液5mg/(次·d),加入5%~10%葡萄糖注射液50~100mL中静脉滴注,3d为1个疗程。结果治疗后,治疗组显效率为51.28%(20/39),对照组为28.21%(11/39),两组比较差异有统计学意义(χ2=4.33,P<0.05);治疗组总有效率为94.87%(37/39),对照组为74.36%(29/39)。两组比较差异有统计学意义(χ2=6.30,P<0.05)。治疗后热退时间、呕吐与腹泻停止时间观察组明显短于对照组(t=14.51、5.81、16.45,P<0.01)。且两组未见明显不良反应。结论核黄素磷酸钠注射液联合布拉氏酵母菌散剂治疗小儿轮状病毒肠炎疗效显著。
Objective To observe the clinical efficacy of riboflavin and sodium phosphate injection in combination with B flagella powder in treating children with rotavirus enteritis (RVE). Methods 78 cases of RVE were randomly divided into control group and treatment group, 39 cases each. Both groups were routine anti-virus treatment. Children in the control group oral administration of B. Cerevisiae powder, <1 year old 0.125g / time, 2 times / d, 1 to 3 years old 0.25g / time, 2 times / d. On the basis of the control group, the treatment group was treated with 5 mg / (d · d) of riboflavin sodium phosphate injection and 50 ~ 100 mL of 5% ~ 10% dextrose injection for one course of treatment. Results After treatment, the effective rate was 51.28% (20/39) in the treatment group and 28.21% (11/39) in the control group. The difference between the two groups was statistically significant (χ2 = 4.33, P <0.05) The efficiency was 94.87% (37/39) in the control group and 74.36% (29/39) in the control group. The difference between the two groups was statistically significant (χ2 = 6.30, P <0.05). After treatment, the thermal withdrawal time, vomiting and diarrhea stopping time in observation group were significantly shorter than those in control group (t = 14.51,5.81,16.45, P <0.01). There was no obvious adverse reaction in both groups. Conclusion Riboflavin and sodium phosphate injection combined with B. burgdorferi powder treatment of pediatric rotavirus enteritis has a significant effect.