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近年来在临床和实验中,发现急性短暂的心肌缺血重灌注后其收缩性常有恢复障碍,甚者可导致心泵衰竭和心律失常。本实验目的在于探讨NTG对急性短暂缺血和再灌注后血肌收缩性有何影响。材料与方法雄性家兔68只,1.8～2.6kg,随机分成四组:第Ⅰ组假手术输生理盐水;第Ⅱ组假于术输NTG;第Ⅲ组心肌缺血输生理盐水;第Ⅳ组心肌缺血NTG。家兔以20%乌拉坦5ml/kg静脉全麻,维持肛温37～39℃,0.1%肝素3ml/kg耳缘静脉注入,全身抗凝。兔仰位固定,气管插管,自主呼吸。自左侧颈
In recent years in clinical and experimental found that acute short-term myocardial ischemia and reperfusion its contraction often have barriers to recovery, worse heart can lead to heart failure and arrhythmia. The purpose of this experiment was to investigate the effect of NTG on the contractility of blood muscle after acute transient ischemia and reperfusion. Materials and Methods 68 male rabbits (1.8-2.6kg) were randomly divided into four groups: sham-operated group received saline; group II received sham-operation NTG; group Ⅲ received saline; group IV Myocardial ischemia NTG. Rabbits with 20% urazan 5ml / kg intravenous anesthesia to maintain rectal temperature 37 ~ 39 ℃, 0.1% heparin 3ml / kg ear vein injection, systemic anticoagulation. Rabbit Yang position fixed, endotracheal intubation, spontaneous breathing. From the left neck