论文部分内容阅读
目的:观察怡肾丸Ⅰ号对单侧输尿管梗阻(UUO)大鼠生化指标及纤维结合蛋白(FN)、Ⅳ型胶原(ColⅣ)的影响。方法:将50只UUO SD大鼠按照完全随机的方法分为空白组、假手术组、模型组、怡肾丸组和依那普利组,分别干预14d后,观察各组大鼠的肌酐(Scr)、尿素氮(BUN)、尿蛋白定量及FN、ColⅣ改变情况。结果:与模型组比较,各组大鼠的生化指标及FN、ColⅣ均明显降低(P<0.05),怡肾丸组对大鼠肌酐、尿蛋白定量优于依那普利组(P<0.05)。结论:怡肾丸Ⅰ号对UUO大鼠的Scr、BUN、尿蛋白定量及FN、ColⅣ有明确改善作用。
Objective: To observe the effect of Yishenwan Ⅰ on the biochemical indexes, fibronectin (FN) and type Ⅳ collagen (Col Ⅳ) of unilateral ureteral obstruction (UUO) rats. Methods: Fifty UUO SD rats were randomly divided into blank group, sham operation group, model group, Yishenwan group and enalapril group. After intervention for 14 days, creatinine Scr, BUN, urinary protein and FN, ColⅣ. Results: Compared with the model group, the biochemical indexes, FN and ColⅣ of rats in each group were significantly lower (P <0.05), and the scores of creatinine and urinary protein in YiShen Pill group were better than that of enalapril group (P <0.05) ). Conclusion: Yishenwan Ⅰ has a clear effect on the quantification of Scr, BUN, urinary protein, FN and ColⅣ in UUO rats.