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目的探讨叶下珠复方肝康对实验性慢性肝损伤的保护作用。方法用ＣＣｌ４建大鼠慢性肝损伤模型，于第５周根据血清ＡＬＴ活力高低分层随机分为５组：ＣＣ１４模型组、乙肝宁组、肝康３个剂量组（９、６、３ｇ／ｋｇ．ｄ），第１０周取血标本查ＡＬＴ、ＡＳＴ、总蛋白及白蛋白，取肝左叶做病理组织学检查。结果与模型组相比，肝康组肝功能明显改善，肝组织结构破坏轻，纤维组织增生程度轻；与乙肝宁组相比，各项指标变化略占优势。结论肝康对实验性慢性肝损伤有保护肝细胞、减少肝损伤、抗肝纤维化作用
Objective To investigate the protective effect of Yexiazhu compound Fanggankang on experimental chronic liver injury. Methods Rat chronic liver injury models were established with CCl4 and randomly divided into five groups according to the level of serum ALT activity at the 5th week: CC14 model group, Yiganing group and Gankang 3 dose group (9, 6, 3g/kg .d) At the 10th week, blood samples were taken for ALT, AST, total protein and albumin, and left hepatic lobe was taken for histopathological examination. Results Compared with the model group, the liver function of the liver and liver group was significantly improved, the structure of the liver tissue was lightly destroyed, and the degree of fibrous tissue proliferation was light. Compared with the group of Yiganing, the changes of each index were slightly dominant. Conclusion Liver-Gan Kang protects hepatocytes, reduces hepatic injury and anti-hepatic fibrosis in experimental chronic liver injury