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目的:探讨膀胱神经内分泌癌的临床特点及病理特征,以提高诊疗水平。方法:介绍1例女性膀胱神经内分泌癌的诊治情况及病理特点,并复习相关文献,综合分析膀胱神经内分泌癌的组织来源,病理和免疫组化特征,诊治及预后。结果:对患者行尿道膀胱肿瘤电切术,术后病理证实为小细胞神经内分泌癌,免疫组化染色结果显示肿瘤细胞表达神经内分泌标记物CK、TTF-1、NSE、CD56、Syn(+)。结论:膀胱神经内分泌癌在泌尿系肿瘤中罕见,有独特的病理特点,预后很差,行根治性切除辅以联合化疗或放疗是目前最佳的治疗方案。
Objective: To investigate the clinical features and pathological features of bladder neuroendocrine carcinoma in order to improve the diagnosis and treatment. Methods: The diagnosis and treatment of female bladder neuroendocrine carcinoma and its pathological features were reviewed. Relevant literatures were reviewed. The source, histopathological and immunohistochemical characteristics of bladder neuroendocrine carcinoma were analyzed. Results: The patients underwent resection of urethra bladder tumor. The histopathology proved to be small cell neuroendocrine carcinoma. Immunohistochemical staining showed that the neuroendocrine markers CK, TTF-1, NSE, CD56, Syn (+) . Conclusions: Bladder neuroendocrine carcinoma is rare in urological tumors. It has unique pathological features and poor prognosis. Radical resection combined with chemotherapy or radiotherapy is the best treatment.