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目的:制备前列腺素E1微乳,并对其进行体外经皮渗透性评价。方法:采用改进的Franz扩散池,进行微乳与乳膏的经皮渗透性评价;考察氮酮、乙醇胺及二者合用对前列腺素E1透皮吸收的影响。结果:前列腺素E1微乳的经皮通透性明显优于乳膏(P<0.01)。氮酮、乙醇胺及二者合用对前列腺素E1的经皮渗透都有显著的促进作用(P<0.01),其中乙醇胺的促渗效果最好。结论:前列腺素E1微乳具有很强的透皮能力,有望成为前列腺素E1的新型经皮给药制剂。
Objective: To prepare prostaglandin E1 microemulsion and evaluate its transdermal permeability in vitro. Methods: The improved Franz diffusion cell was used to evaluate the transdermal permeability of microemulsion and cream. The effects of azone, ethanolamine and their combination on transdermal absorption of prostaglandin E1 were investigated. Results: Percutaneous permeability of prostaglandin E1 microemulsion was significantly better than that of cream (P <0.01). Azone, ethanolamine and their combination promoted the transdermal penetration of prostaglandin E1 significantly (P <0.01), and the effect of ethanolamine was the best. Conclusion: Prostaglandin E1 microemulsion has strong transdermal ability and is expected to become a new transdermal drug delivery preparation for prostaglandin E1.