研究五灵脂提取液ＷＬＺＢ１、ＷＬＺＢ２、ＷＬＺＢ３对胃粘膜的保护作用．方法用Ｓｈａｙ模型和利血平模型，大白鼠随机分为生理盐水对照组、五灵脂提取液组和雷尼替丁（Ｒａｎ）组．三个提取液分别配成相当于生药２、４、８ｇ／ｍｌ溶液．Ｒａｎ配成３０ｍｇ／ｍｌ．分别用１ｍｌ／１００ｇ动物体重的剂量作腹腔注射，１０ｈ～１６ｈ后处死动物，剖胃收集胃液并计算胃液量、胃酸ｐＨ值和胃粘膜损伤指数．结果Ｓｈａｙ模型中，ＷＬＺＢ１组剂量相当于生药４０和８０ｇ／ｋｇ鼠胃粘膜损伤指数分别为８６±１０８、１６±１９，明显少于生理盐水对照组４７０±３１４（Ｐ＜００５；Ｐ＜００１），后者粘膜损伤指数（１６±１９）亦少于Ｒａｎ组（２０５±１６４，Ｐ＜００１），而胃酸ｐＨ值（３４２５±０１４３）则高于生理盐水对照组（２８６３±０６３２，Ｐ＜００５）．利血平模型中，ＷＬＺＢ１相当于生药４０ｇ／Ｋｇ组，鼠胃粘膜损伤指数（２０７±１６５）少于生理盐水组（７６３±５０６，Ｐ＜００５）．结论五灵脂提取液Ｂ１有显著的胃粘膜保护作用及抑制胃酸分泌的作用． Study Wulingzhi extract WLZ B1, WLZ B2, WLZ B3 protective effect on the gastric mucosa. Methods Shay model and reserpine model were used. The rats were randomly divided into normal saline control group, Wulingzhi extract group and ranitidine group. The three extracts were dubbed the equivalent of crude drug 2,4,8 g / ml solution. Ran dubbed 30mg / ml. Animals were injected intraperitoneally with 1ml / 100g animal body weight respectively. Animals were sacrificed 10h ~ 16h later. Gastric juice was collected through the stomach and the gastric juice volume, gastric acid pH value and gastric mucosal damage index were calculated. Results Shay model, WLZ  B1 group dose equivalent to crude drug 40 and 80g / kg gastric mucosal damage index were 8  6  10  8,1  6 ± 1  9, significantly less than the saline control group 47  0 ± 314 (P <005; P <001), while mucosal lesion index (16 ± 19) in the latter group was also less than that in Ran group (205 ± 164, P <0)  01), while the gastric acid pH value (3425 ± 0143) was higher than that of saline control group (2863 ± 0632, P <005). In reserpine model, WLZB1 was equivalent to 40g / Kg crude drug, and gastric mucosal lesion index (207 ± 165) in rats was less than that in saline group (763 ± 506, P <005 ). Conclusion Wulingzhi extract B1 has significant gastric mucosal protective effect and inhibition of gastric acid secretion.