论文部分内容阅读
目的观察苯巴比妥预防新生儿缺氧缺血性脑病(HIE)的疗效及对患儿脑脊液中超氧化物歧化酶(SOD)和丙二醛(MDA)含量的影响。方法将47例有HIE病因患儿随机分为苯巴比妥预防组与对照组,比较两组患儿HIE发病情况,所有患儿均于生后10~12h间采集脑脊液标本,检测并比较两组患儿脑脊液中SOD、MDA含量。结果预防组HIE发病率明显低于对照组,并且中、重型HIE发病率也明显低于对照组。与对照组比较预防组脑脊液SOD活性与MDA含量均显著降低。结论苯巴比妥对HIE有明显的防治作用,其作用可能与清除自由基、减少脂质过氧化有关。
Objective To observe the efficacy of phenobarbital in preventing neonatal hypoxic-ischemic encephalopathy (HIE) and its effect on the content of superoxide dismutase (SOD) and malondialdehyde (MDA) in cerebrospinal fluid of children. Methods Forty-seven children with HIE etiology were randomly divided into phenobarbital prophylaxis group and control group. The incidence of HIE in both groups was compared. All children were collected cerebrospinal fluid from 10 to 12 h after birth to detect and compare two Group of children with cerebrospinal fluid SOD, MDA content. Results The incidence of HIE in prevention group was significantly lower than that in control group, and the incidence of HIE in middle and severe HIE was also significantly lower than that in control group. Compared with the control group, the activity of SOD and the content of MDA in cerebrospinal fluid in prevention group were significantly decreased. Conclusion Phenobarbital has a significant preventive and therapeutic effect on HIE, which may be related to scavenging free radicals and reducing lipid peroxidation.