论文部分内容阅读
【目的】探讨白细胞活化黏附因子（ALCAM）、基质金属蛋白酶-1（MMP-1）及 MMP-9在人脑膜瘤中的表达及临床意义。【方法】回顾性分析脑膜瘤患者80例，根据病理分非侵袭组44例；侵袭组36例。采用免疫组化技术检测术后 ALCAM、MMP-1及 MMP-9的表达。【结果】ALCAM、MMP-1及 MMP-9在侵袭组脑膜瘤中的表达均高于非侵袭组（P＜0．01）。在侵袭性脑膜瘤中 ALCAM、MMP-1和 MMP-9两两比较，其表达均具有相关性。【结论】ALCAM、MMP-1和 MMP-9与脑膜瘤的侵袭性相关，一定程度上可作为评价脑膜瘤侵袭性及预后的辅助指标，通过术后免疫组化检查可判断脑膜瘤的潜在侵袭性，指导临床治疗方案的制定，提高疗效水平。“,”[Objective]To explore the expression of activated leukocyte cell adhesion molecule(ALCAM), matrix metalloproteinase-1(MMP-1)and matrix metalloproteinase-9(MMP-9)in human meningioma and its clinical significance.[Methods]A total of 80 patients with meningioma were analyzed retrospectively.Accord-ing to the pathology,all patients were divided into non-invasion group(n=44)and invasion group(n=36). Immunohistochemical method was used to detect the expression of ALCAM,MMP-1 and MMP-9 after opera-tion.[Results]The expressions of ALCAM,MMP-1 and MMP-9 in invasion group were higher than those in non-invasion group(P<0.01).There was correlation among the expressions of ALCAM,MMP-1 and MMP-9 in invasive meningioma.[Conclusion]ALCAM,MMP-1 and MMP-9 are correlated with the invasiveness of meningioma and can be used as the auxiliary indexes for evaluating the invasiveness and prognosis of meningio-ma.Immunohistochemical examination can determine the potential invasiveness of meningioma,guide clinical treatment and improve clinical efficacy.