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4-吡哆硫醇通过Ⅹ→Ⅺ→Ⅻ→Ⅰ路线制备,除了三种重要的吡哆醇类:吡哆醇、吡哆醛和吡哆胺外,4,5,和4,5位含硫的维生素B_6衍生物不久以前才开始被研究。 4-吡哆硫醇(Ⅰ)的合成有许多方法:①由2-甲基-3氨基-4-甲氧甲基-5-氨甲基吡啶的3-氨基选择性重氮化而得相应之醇类,再制得相应之溴化物与硫代乙酸反应而得化合物Ⅲ。与Ⅳ可直接转变成Ⅰ。②由吡哆醇(Ⅴ)的第3位和第4位缩醛化(如Ⅵ)或乙酰化(如ⅩⅥ)保护后,5-位羟基经苯甲酰化(如Ⅶ或ⅩⅦ),小心地水解使3,4位游离出(Ⅹ的形成),在第4位上再引入氯(Ⅺ)再为巯基所置换(Ⅻ),由Ⅻ的苯甲酸酯水解而得4-吡哆硫醇(Ⅰ)
The 4-pyridoxylthiol is prepared by the route X → XI → Ⅻ → I, except for the three important pyridoxins: pyridoxine, pyridoxal and pyridoxamine, and the 4,5, and 4,5 positions Sulfur vitamin B_6 derivatives have only recently been studied. There are many ways to synthesize 4-pyridoxylthiol (Ⅰ): ① By the 3-amino selective diazotization of 2-methyl-3-amino-4-methoxymethyl-5-aminomethyl pyridine, Of the alcohols, and then the corresponding bromide and thioacetic acid reaction compound III. And Ⅳ can be directly converted to Ⅰ. ② After benzopyrification of the hydroxyl group at the 5-position (eg VII or XVII) after acetalization (eg VI) or acetylation (eg XVI) at positions 3 and 4 of pyridoxine (V) Hydrolysis of 3,4-bit free (X formation), in the fourth place on the re-introduction of chlorine (Ⅺ) and then replaced by the mercapto (Ⅻ), from the Ⅻ benzoate hydrolysis 4-pyridoxine Alcohol (I)