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目的探讨早期胃癌淋巴转移临床病理相关因素,预测淋巴转移风险。方法收集浙江大学医学院附属第二医院2006-2009年214例早期胃癌标本,利用二元Logistic回归模型分析患者年龄、性别、形态、病灶大小、浸润深度、病理组织学、及脉管侵犯等因素与早期胃癌淋巴转移相关性。结果 Logistic回归分析提示病灶大小[OR=2.014,95%置信区间CI(1.049~3.865),P=0.035]、浸润深度[OR=7.112,95%CI(2.484~20.362),P<0.001]、病理组织学[OR=3.353,95%CI(1.294~8.690),P=0.013]、脉管侵犯[OR=2.812,95%CI(1.043~7.583),P=0.041]与淋巴转移相关。结论肿瘤病灶大小、浸润深度、病理组织学及脉管侵犯是早期胃癌淋巴转移的独立风险预测因子。
Objective To investigate the clinicopathological factors of lymphatic metastasis in early gastric cancer and predict the risk of lymphatic metastasis. Methods Totally 214 early gastric cancer samples collected from the Second Affiliated Hospital of Zhejiang University from 2006 to 2009 were analyzed with the binary Logistic regression model to analyze the factors such as age, sex, morphology, size, depth of invasion, histopathology and vascular invasion Correlation with lymphatic metastasis of early gastric cancer. Results Logistic regression analysis showed that the size of the lesion (OR = 2.014, 95% confidence interval CI 1.049 to 3.865, P 0.035), depth of invasion (OR 7.112, 95% CI 2.484 to 20.362, P 0.001) Histology (OR = 3.353, 95% CI 1.294-8.690, P = 0.013) and vessel invasion (OR 2.812, 95% CI 1.043-7.583, P 0.041) were associated with lymphatic metastasis. Conclusion The tumor size, depth of invasion, histopathology and vascular invasion are independent risk predictors of lymphatic metastasis in early gastric cancer.