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为了观察卡托普利注射液治疗高血压危象的疗效,将46例患者分为两组进行临床对照试验。治疗组29例,给予卡托普利注射液10mg静滴;对照组17例,给予硝普钠注射液25mg静滴,均为一次性给药比较疗效,两组有效率分别为93.1％、94.1％(治疗前后比较均P<0.01,两组间比较P>0.05),起效时间均为10～40分钟,维持时间对照组仅数分钟,治疗组2h左右(P<0.01)。结果表明:卡托普利注射液降血压作用显著,起效快,维持时间较长、副作用少,疗效确切,安全可靠。
In order to observe the efficacy of captopril injection in the treatment of hypertensive crisis, 46 patients were divided into two groups for clinical trial. The treatment group (n = 29) received captopril injection (10 mg) intravenously. The control group (n = 17) received sodium nitroprusside injection (25 mg) intravenously for one time. The effective rates were 93.1%, 94.1 % (P <0.01 before and after treatment, P> 0.05 between the two groups). The onset time was 10 to 40 minutes. The maintenance time was only a few minutes in the control group, and the treatment group was about 2 hours (P <0.01). The results showed that captopril injection had significant antihypertensive effect, fast onset of action, long maintenance time, less side effects, exact curative effect and safety.