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组蛋白的甲基化和乙酰化修饰对基因转录作用已比较清楚,并明确其参与了肿瘤发生。对于组蛋白泛素化,近年来的研究认识表明其对转录有双重作用与肿瘤发生关系密切。
Histone methylation and acetylation of the gene transcription has been more clear, and clearly involved in tumorigenesis. For histone ubiquitination, recent studies have shown that it has a dual role in transcription and tumor closely related.