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目的探讨不稳定性心绞痛患者血浆同型半胱氨酸(Hcy)和高敏C反应蛋白(hsCRP)水平与冠状动脉病变程度的关系。方法不稳定型心绞痛(UAP)组52例,另设性别、年龄相匹配经冠脉造影排除冠心病的患者作为对照组(35例)。所有研究对象均于入院后空腹采血后分离血浆,检测血浆Hcy和hsCRP,经冠状动脉造影检查后采用Gemini法评估冠脉病变狭窄程度。结果不稳定性心绞痛组与对照组患者Hcy分别为(14.5±3.9)μmol/L,(7.95±2.8)μmol/L(P<0.05);hsCRP分别为(8.7±1.3)μmol/L,(2.7±1.2)μmol/L(P<0.05),Hcy在不稳定性心绞痛患者中随着冠脉病变程度的加重而升高,而hsCRP水平与冠脉病变程度无相关性。结论随着冠脉病变程度的增加,血浆Hcy水平增高,而hsCRP不与冠脉严重程度成正相关,通过测定Hcy可以反映冠脉狭窄的严重程度,而测定CRP可以反映冠脉不稳定斑块的活动程度。
Objective To investigate the relationship between plasma homocysteine (Hcy) and high-sensitivity C-reactive protein (hsCRP) levels and coronary artery lesion in patients with unstable angina pectoris. Methods Fifty-two patients with unstable angina pectoris (UAP) were enrolled as control group (35 cases) with gender and age matched coronary angiography. All subjects were fasting plasma after admission, plasma separation, detection of plasma Hcy and hsCRP, after coronary angiography using Gemini method to assess coronary artery stenosis. Results Hcy was (14.5 ± 3.9) μmol / L and (7.95 ± 2.8) μmol / L respectively in patients with unstable angina and control group (8.7 ± 1.3) μmol / L and ± 1.2) μmol / L (P <0.05). The level of Hcy in patients with unstable angina pectoris increased with the degree of coronary artery disease, while the level of hsCRP had no correlation with the degree of coronary artery disease. Conclusions As the degree of coronary artery disease increases, plasma Hcy level increases, but hsCRP level is not positively correlated with the severity of coronary artery disease. Hcy can reflect the severity of coronary artery stenosis. CRP can reflect the level of coronary artery plaque Activity level.