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目的:探讨榄香烯注射液辅助治疗肺癌脑转移患者的临床疗效。方法:将2012年6月-2014年9月某院收治的84例肺癌脑转移患者随机分为观察组和对照组,对照组采用常规放疗治疗,观察组采用榄香烯辅助放疗治疗,按RECIST制定的实体瘤客观疗效评定标准进行疗效评定,2组患者的生活质量应用卡式评分法评定。结果:观察组有效率(CR+PR)为52.4%,明显高于对照组的28.6%,差异有统计学意义(P<0.05);2组治疗后KSP评分观察组有效率为81.0%,对照组为50.0%,差异有统计学意义(P<0.05);对照组骨髓抑制、放射性肺炎、头痛、恶心、呕吐等不良反应发生率为73.8%(31/42),观察组为31.0%(13/42),差异有统计学意义(P<0.05)。结论:榄香烯注射液辅助治疗肺癌脑转移患者有助于改善临床症状,增加放疗效果,改善患者生活质量,可在临床上推广。
Objective: To investigate the clinical efficacy of elemene injection in the treatment of patients with brain metastasis of lung cancer. Methods: From June 2012 to September 2014, 84 patients with brain metastases from lung cancer were randomly divided into observation group and control group. The control group received conventional radiotherapy and the observation group received elemene radiotherapy. According to RECIST The curative effect was evaluated according to the evaluation criteria of objective curative effect of solid tumors. The quality of life of two groups of patients was evaluated by the scorecard method. Results: The effective rate (CR + PR) in observation group was 52.4%, which was significantly higher than that in control group (28.6%), the difference was statistically significant (P <0.05). The effective rate of KSP score observation group was 81.0% The incidence of adverse reactions such as bone marrow suppression, radiation pneumonitis, headache, nausea and vomiting was 73.8% (31/42) in the control group and 31.0% (13.0%) in the observation group (50.0%, P 0. 05) / 42), the difference was statistically significant (P <0.05). Conclusion: Elemene injection in patients with brain metastases of lung cancer can help to improve clinical symptoms, increase radiotherapy and improve the quality of life of patients, which can be popularized clinically.