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目的:观察肝源性溃疡的特点,探讨小剂量普奈洛尔对肝源性溃疡愈合的影响。方法:将本院121例明确诊断为肝源性溃疡(HU)患者,随机分为治疗组(A组)61例及对照给(B组)60例。治疗组予奥美拉唑20mgBid(4周)+克拉霉素500mgBid(1周)+阿莫西林1000mgBid(1周)+普奈洛尔10mgtid(4周)进行治疗。对照组单纯三联法治疗。4周后随访,胃镜复查,确定症状缓解率及溃疡愈合情况。结果:治疗4周后症状缓解率两组间无显著差异(P>0.05)。胃镜复查溃疡愈合例数两组间存在显著差异(P<0.05)。结论:小剂量普奈洛尔联合奥美拉唑三联疗法有助于肝源性溃疡(HU)愈合。
Objective: To observe the characteristics of liver-derived ulcer and explore the effect of small dose of propranolol on the healing of liver-derived ulcer. Methods: 121 patients with definite diagnosis of liver ulcer (HU) in our hospital were randomly divided into treatment group (group A) 61 and control group B (group B) 60. Treatment groups were treated with omeprazole 20 mg Bid (4 weeks) + clarithromycin 500 mg Bid (1 week) + amoxicillin 1000 mg Bid (week 1) + propranolol 10 mgtid (4 weeks). Control group therapy alone triple therapy. Follow-up after 4 weeks, gastroscopy review to determine the rate of symptom relief and ulcer healing. Results: There was no significant difference between the two groups after 4 weeks of treatment (P> 0.05). There were significant differences between the two groups in the number of ulcer healing (P <0.05). CONCLUSIONS: Small doses of propranolol combined with omeprazole triple therapy contribute to the healing of liver-derived ulcers (HU).