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生长分化因子-15(growth differentiation factor-15,GDF-15)是转化生长因子β(transforming growth factorβ,TGF-β)超家族成员的一个远支,是一个重要的心血管保护因子。作为新的标志物,GDF-15水平与多种心血管疾病的诊断、危险分层和预后判断有密切关系。本文就GDF-15基因的生物学特点及其在心血管疾病中的多种功能作一综述。
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor β (TGF-β) superfamily and is an important cardiovascular protective factor. As a new marker, the level of GDF-15 is closely related to the diagnosis, risk stratification and prognosis of various cardiovascular diseases. This article reviews the biological characteristics of GDF-15 gene and its multiple functions in cardiovascular diseases.