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[目的]观察补肺汤联合沙丁胺醇治疗小儿慢性支气管炎疗效。[方法]使用随机平行对照方法,将60例住院患者按病历号抽签随机分为两组。对照组30例沙丁胺醇5mg+0.9%氯化钠4m L,4L/min雾化吸入,15~20min/次,2次/d。治疗组30例补肺汤(当归15g,黄芪60g,熟地黄15g,丹参20g,白术15g,半夏、制麻黄各10g,五味子、麦冬、茯苓各15g,蛤蚧6g),水煎150m L,1剂/d,早晚分服;沙丁胺醇治疗同对照组。连续治疗7d为1疗程。观测临床症状、咳嗽、咳痰、动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)、不良反应。治疗1疗程(7d),判定疗效。[结果]治疗组临床控制14例,显效10例,有效4例,无效2例,总有效率93.33%;对照组临床控制8例,显效7例,有效7例,无效8例,总有效率73.33%;治疗组疗效优于对照组(P<0.05)。PaO_2、PaCO_2两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]补肺汤联合沙丁胺醇雾化吸入治疗小儿慢性支气管炎,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the effect of Bufei Decoction combined with salbutamol on children with chronic bronchitis. [Methods] Randomized parallel control method was used to divide 60 inpatients according to their medical record numbers into two groups randomly. The control group 30 patients salbutamol 5mg + 0.9% sodium chloride 4m L, 4L / min inhalation, 15 ~ 20min / times, 2 times / d. The treatment group, 30 cases of Bufei Decoction (Angelica 15g, Astragalus 60g, Rehmannia 15g, Salvia 20g, Atractylodes 15g, Pinellia, Ephedra each 10g, Schisandra, Radix, Poria 15g, Gecko 6g), decoction 150m L, 1 dose / d, morning and evening sub-service; salbutamol treatment with the control group. Continuous treatment 7d for a course of treatment. Clinical symptoms, cough, sputum, arterial partial pressure of oxygen (PaO_2), arterial partial pressure of carbon dioxide (PaCO_2) and adverse reactions were observed. Treatment of a course of treatment (7d), to determine the efficacy. [Results] In the treatment group, 14 cases were clinically controlled, 10 cases were markedly effective, 4 cases were effective, 2 cases were ineffective and the total effective rate was 93.33%. In the control group, 8 cases were clinically controlled, 7 cases markedly effective, 7 effective and 8 ineffective. The total effective rate 73.33%. The curative effect in treatment group was better than that in control group (P <0.05). PaO_2, PaCO_2 were improved in both groups (P <0.01), the treatment group improved better than the control group (P <0.01). [Conclusion] Bufei Decoction combined with salbutamol inhalation therapy for children with chronic bronchitis has satisfactory curative effect and no serious adverse reactions, which deserves promotion.