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背景及目的:一些研究提示,哮喘患者β2肾上腺素受体第16位氨基酸位点为精氨酸纯合子(B16 Arg/Arg)比甘氨酸纯合子(B16 Gly/Gly)对长效β2受体激动剂和吸入性皮质类固醇的治疗反应要弱。本文探讨了在长效β2受体激动剂和吸入性皮质类固醇联合治疗时是否有基因型特异性反应。
BACKGROUND & AIM: Some studies suggest that the 16th amino acid site of β2 adrenergic receptor in asthma patients is agonist of long-acting β2 receptor by B16 Arg / Arg and B16 Gly / Gly Agents and inhaled corticosteroids are less likely to respond to treatment. This article explores whether there is a genotype-specific response to a combination of long-acting β2-agonist and inhaled corticosteroid.