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AIM: To study the histopathological changes in the retina and flash electroretinogram(F-ERG) features of ozone-treated streptozotocin(STZ)-induced diabetic rats.METHODS: Seventy male Sprague Dawley rats were grouped as follows: blank group(GB, n =10), model control group(GM, n =18), ozone group(GO3, n =19), and oxygen group(GO2, n =18). The model was induced by single intraperitoneal injection of STZ. Ozone or oxygen enteroclysm was given twice per week for 4wk. F-ERG and histopathological examinations were performed one month after treatment.RESULTS: Under dark adaption, as compared to GB,the other groups each had differential decreases in the a-wave amplitudes(P <0.05); the latencies were delayed in GM, GO2, and GO3rats(P <0.05). Similar results were observed under light adaption, with the exception that the a-wave of the amplitudes(F =0.28, P >0.05). There were significant differences in the apoptosis index among the groups(P <0.05). Under ozone treatment,apoptosis was decreased in GO3 as compared to GM and GO2.CONCLUSION: Ozone administration alleviates nerve damage and reduces pathology and apoptosis in the retinas of diabetic rats.
AIM: To study the histopathological changes in the retina and flash electroretinogram (F-ERG) features of ozone-treated streptozotocin (STZ) -induced diabetic rats. METHODS: Seventy male Sprague Dawley rats were grouped as follows: blank group (GB, n = 10), model control group (GM, n = 18), ozone group (GO3, n = 19), and oxygen group (GO2, n = 18). The model was induced by single intraperitoneal injection of STZ. Enteroclysm was given twice per week for 4 weeks. FULTS: Under dark adaption, as compared to GB, the other groups each had differential decreases in the a-wave amplitudes (P <0.05 ; the latencies were delayed in GM, GO2, and GO3rats (P <0.05). Similar were observed under light adapttion, with the exception that the a-wave of the amplitudes (F = 0.28, P> 0.05). Significant differences in the apoptosis index among the groups (P <0.05). Under ozone treatment, apoptosis was decreased in GO3 as compared to GM and GO2. CONCLUSION: Ozone administration alleviates nerve damage and reduces pathology and apoptosis in the retinas of diabetic rats.