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最近的实验和临床研究提示H_2-受体拮抗剂甲氰咪胍(Cimeddine)能保护胃粘膜以防止急性溃疡;但抗酸剂预防危重病人急性上消化道出血亦很有效,唯常有腹泻等副作用,而且须每小时给服药并检测胃液pH。本文目的在于比较甲氰咪胍和抗酸剂二者在预防急性胃肠道出血中,哪种更为有效。作者等对监护病房中75例危重病人随机分为两组,甲氰咪胍组38例(男女各19例,平均年龄62岁),
Recent experimental and clinical studies suggest that H 2 -receptor antagonist Cimeddine protects the gastric mucosa against acute ulcers; antacids are also effective in preventing acute upper gastrointestinal bleeding in critically ill patients, often with diarrhea, etc. Side effects, but also to be given every hour and test gastric juice pH. The purpose of this article is to compare cimetidine and antacids in the prevention of acute gastrointestinal bleeding, which is more effective. The author of the intensive care unit in 75 cases of critically ill patients were randomly divided into two groups, cimetidine group of 38 patients (19 men and women, mean age 62 years)