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NGX6基因是本研究室在鼻咽癌 9p最小共同缺失区内新克隆的鼻咽癌候选抑瘤基因。通过采用病例 对照研究方法 ,利用动态等位基因杂交 (DASH)技术对 10 5例鼻咽癌患者和 183例正常人NGX6基因的 2个单核苷酸多态 (SNP)进行了分型 ,经相关分析发现 ,位于NGX6基因上游调控区的SNPrs8792 84与鼻咽癌发病存在显著相关性 ,基因型CT和TT的相对危险度分别为 3.93和 2 .2 7。实验结果进一步支持了NGX6基因与鼻咽癌的发生发展可能存在密切关系 ,SNPrs8792 84由于处在NGX6基因上游调控区域 ,其多态类型可能在某种程度上影响NGX6基因的表达调控 ,从而与鼻咽癌发病相关
NGX6 gene is a nasopharyngeal cancer candidate tumor suppressor gene newly cloned by our laboratory in the smallest common deletion region of NPC 9p. Two single nucleotide polymorphisms (SNPs) of NGX6 gene in 105 patients with nasopharyngeal carcinoma and 183 normal subjects were genotyped by dynamic allelic hybridization (DASH) using a case-control study. Correlation analysis showed that SNP rs8792 84 located upstream of NGX6 gene was significantly associated with the pathogenesis of NPC, and the relative risk of genotype CT and TT were 3.93 and 2.27, respectively. The results further support NGX6 gene and nasopharyngeal carcinoma may be closely related to the occurrence and development of SNP rs8792 84 in the NGX6 upstream regulatory region, the polymorphism may affect the expression of NGX6 gene to some extent, and thus the nose Related to the incidence of pharyngeal cancer