目的探讨加倍维持剂量的硫酸氢氯吡格雷在经皮冠状动脉介入治疗(PCI)术后应用的效果及安全性。方法选择行PCI术的易栓患者50例,术后一段时期内硫酸氢氯吡格雷维持量加倍,观察临床效果及心血管事件发生情况,及对血液、消化系统影响。结果硫酸氢氯吡格雷加倍维持剂量显示更好的抗栓效果,无明显副作用。结论 PCI术后采用加倍剂量的维持量,安全有效,尤其对易栓、高危、超重及消化道出血的患者不失为较好的抗栓策略。 Objective To investigate the effect and safety of doubled maintenance dose of clopidogrel hydrogen sulfate in percutaneous coronary intervention (PCI). Methods Fifty patients with thrombolytic therapy were selected. The maintenance dose of Clopidogrel Hydrochloride was doubled after a period of operation. The clinical effect, cardiovascular events and blood and digestive system were observed. Results Clopidogrel bisulfate dosing maintenance dose showed better antithrombotic effect, no obvious side effects. Conclusion It is safe and effective to use twice the dose of maintenance dose after PCI. It is a good antithrombotic strategy for patients with thrombolytic, high risk, overweight and gastrointestinal bleeding.