论文部分内容阅读
[目的 ]观察二金汤方对功能性消化不良 (FD)大鼠胃窦部肥大细胞数量和血清一氧化氮 (NO)的影响 ,探讨其可能的作用机制。 [方法 ]采用不规则进食加稀酸喂养制作大鼠FD模型 ,并随机分成二金汤大、小剂量、多潘立酮、0 .85 %氯化钠液 (正常 )及模型组 ,共 5组 ,连续给药 2 8d后 ,以硝酸还原酶法测定血清NO ;中性红染色法对胃窦黏膜肥大细胞进行计数。 [结果 ]与正常组相比 ,模型组大鼠血清NO和胃窦黏膜肥大细胞计数增多 (P <0 .0 5 )。二金汤大剂量组血清NO和胃窦部肥大细胞数较模型组显著降低 (P <0 .0 5 ) ,与正常组相仿。 [结论 ]二金汤方具有降低血清NO和胃窦部肥大细胞数作用 ,可能是其治疗FD的机制。
[Objective] To observe the effect of Erjin Tang recipe on the number of gastric antrum mast cells and serum nitric oxide (NO) in rats with functional dyspepsia (FD), and to explore its possible mechanism. [Methods] Rat FD model was made by feeding irregularly and dilute acid and randomly divided into two groups: big gold, small dose, domperidone, 0.85% sodium chloride solution (normal) and model group. There were 5 groups in total. After 28 days, serum NO was measured by nitrate reductase method; gastric mucosal mast cells were counted by neutral red staining. [Results] Compared with the normal group, serum NO and gastric mast cell mast cell counts increased in the model group (P < 0.05). The serum NO and antrum mast cell counts in the high-dose group of Erjintang group were significantly lower than those in the model group (P < 0.05), similar to the normal group. [Conclusion] The effect of Erjin Tangfang on reducing serum NO and mast cell number in gastric antrum may be the mechanism of treating FD.