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目的了解杭州地区新生儿及婴儿TORCH感染状况及临床特点。方法应用ELISA法检测1 220例新生儿和婴儿血清中的TORCH特异性抗体,并进行相关分析。结果受检患儿中TORCH-Ig M阳性率为2.3%,其中以CMV感染为主,婴儿期CMV-Ig M阳性率达9.2%;患儿中TORCH-Ig G抗体阳性率为98.3%,其中单一病原体感染者Ig G抗体检出构成比为9.8%,病原体以HSVⅠ最常见;多重感染中,3种病原体感染者最多,Ig G抗体检出构成比为56.2%,病原体组合模式以HSVⅠ、RV、CMV为最多,构成比为53.3%;分组比较新生儿及婴儿Ig G抗体检测均以HSVⅠ-Ig G抗体阳性率最高,分别为94.0%、68.9%,其次是CMV-Ig G,分别为90.2%、64.7%;CMV-Ig M阳性患儿临床疾病类型以肺炎和支气管炎为主。结论 TORCH感染在新生儿及婴儿期发生率高,婴儿期需警惕CMV感染,应及早筛查,降低出生缺陷和死亡率。
Objective To investigate the status and clinical features of TORCH infection in neonates and infants in Hangzhou area. Methods TORCH-specific antibodies in serum of 1 220 neonates and infants were detected by ELISA and analyzed. Results The positive rate of TORCH-Ig M was 2.3%. The positive rate of CMV-Ig M was 9.2% in infants. The positive rate of TORCH-Ig G antibody in infants was 98.3% The detection rate of IgG was 9.8% for single pathogen infection and HSVⅠ for pathogen. Among the three infections, the most common pathogen was IgA, the detection ratio of Ig G was 56.2%, the pathogen combination mode was HSVⅠ, RV , And CMV was the most, with a ratio of 53.3%. The positive rate of HSVⅠ-Ig G antibody in group B and group B was the highest (94.0% and 68.9%, respectively), followed by CMV-Ig G %, 64.7%. The clinical types of CMV-Ig M-positive children were mainly pneumonia and bronchitis. Conclusion The incidence of TORCH infection in neonates and infants is high. CMV infection should be observed in infancy. Screening should be conducted early to reduce birth defects and mortality.