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目的评估钙卫蛋白在区分功能性和器质性肠道疾病中的价值。方法选取2011年2月至2013年8月就诊于河南省镇平县人民医院消化科的有下消化道症状的患者72例。其中功能性肠道疾病患者25例,器质性疾病患者47例(炎性肠道疾病患者24例,非炎性的器质性肠道疾病患者23例)。选取健康体检者25例作为对照。留取粪便用酶联免疫法对钙卫蛋白进行检测。结果炎性肠道疾病(IBD)患者FCP水平为489.1(349.6~1620.3)μg/g,显著高于功能性肠道疾病患者(IBS)FCP水平[26.8(18.6~58.8)μg/g;P<0.001]和健康对照组FCP水平[25.3(18.9~29.9)μg/g;P<0.001]。非炎性的器质性肠道疾病患者FCP水平为298.3(148.2~496.2)μg/g,显著高于功能性肠道疾病患者(IBS)FCP水平(P<0.001)和健康对照组FCP水平(P<0.001)。功能性肠道疾病患者FCP水平与健康对照组相比无显著差异(P=0.535)。当Cut off值为60μg/g时,FCP诊断器质性肠道疾病的敏感性100%,特异性88%,阳性预测值88.7%,阴性预测值100%。结论粪钙卫蛋白是一个敏感无创的检查,可用于鉴别功能性和器质性肠道疾病。
Objective To assess the value of calprotectin in distinguishing functional and organic intestinal diseases. Methods Seventy-two patients with lower gastrointestinal symptoms who visited the Department of Gastroenterology, People’s Hospital of Zhenping County, Henan Province from February 2011 to August 2013 were selected. Among them, there were 25 patients with functional bowel disease, 47 patients with organic disease (24 patients with inflammatory bowel disease and 23 patients with non-inflammatory organic intestinal disease). Twenty-five healthy subjects were selected as control. Fecal retention by enzyme-linked immunosorbent assay for calprotectin. Results The FCP level in patients with IBD was 489.1 (349.6-1620.3) μg / g, significantly higher than that of patients with functional bowel disease (IBS) [26.8 (18.6-58.8 μg μg / g; P < 0.001] and FCP levels in healthy controls [25.3 (18.9-29.9) μg / g; P <0.001]. FCP levels were 298.3 (148.2- 496.2) μg / g in patients with non-inflammatory organic intestinal disease, significantly higher than those in patients with functional bowel disease (IBS) (P <0.001) and healthy controls P <0.001). There was no significant difference in FCP level between patients with functional bowel disease and healthy controls (P = 0.535). FCP was found to have 100% sensitivity, 88% specificity, 88.7% positive predictive value, and 100% negative predictive value at a Cutoff value of 60 μg / g. Fecal calprotectin is a sensitive, noninvasive test that can be used to identify functional and organic intestinal diseases.