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至今在阿米巴治疗方面最大的进展就是发现了5-硝基咪唑衍生物的杀阿米巴作用。ornidazole 乃硝咪唑衍生物之一,在实验性阿米巴感染时该药甚至比甲硝哒唑更有效。ornidazole 治疗急性阿米巴痢疾的一般剂量疗程为1～1.5g/天,连服5～10天,其治愈率可达90%以上。本项研究的目的是想阐明是否能进一步减少剂量和缩短疗程而不影响疗效。本文作者在巴西、智利和墨西哥的4个试验中心进行了统一的观察研究。治疗对象为具有肠阿米巴病症状并在大便中找到溶组织阿米巴包囊和/或滋养体的190例急性患者。所给剂量疗程为每天晚饭后1次口服 ornidazole 1.5g,连服3天。为考察疗效,分
So far the biggest advance in the treatment of amoeba is found 5-nitroimidazole derivatives of the role of amoeba. Ornidazole is one of the derivatives of nimidazole, which is even more effective than metronidazole in experimental amoebic infections. Ornidazole for the treatment of acute general amyloid dysentery dose of 1 ~ 1.5g / day, and even for 5 to 10 days, the cure rate of up to 90%. The purpose of this study was to elucidate whether further reductions in dosage and duration of treatment can be achieved without compromising efficacy. The authors conducted a unified observational study at four pilot centers in Brazil, Chile and Mexico. The treated subjects were 190 acute patients with enteroeamiasis symptoms and finding dissolved tissue amoeba cysts and / or trophozoites in the stool. The dose given to the course of daily oral administration of ornidazole 1.5g, even for 3 days. To investigate the efficacy, points